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从药物治疗到药物预防:1997-2006 年加拿大安大略省老年患者处方用药趋势。

From pharmaco-therapy to pharmaco-prevention: trends in prescribing to older adults in Ontario, Canada, 1997-2006.

机构信息

Primary Care Research Unit, Sunnybrook Health Sciences Centre, 2075 Bayview Ave, Room E3-49, Toronto, ON M4N3M5, Canada.

出版信息

BMC Fam Pract. 2010 Oct 7;11:75. doi: 10.1186/1471-2296-11-75.

Abstract

BACKGROUND

The developed world is undergoing a demographic transition with greater numbers of older adults and higher rates of chronic disease. Most elder care is now provided by primary care physicians, who prescribe the majority of medications taken by these patients. Despite these significant trends, little is known about population-level prescribing patterns to primary care patients aged 65+.

METHODS

We conducted a population-based retrospective cohort study to examine 10-year prescribing trends among family physicians providing care to patients aged 65+ in Ontario, Canada.

RESULTS

Both crude number of prescription claims and prescription rates (i.e., claims per person) increased dramatically over the 10-year study period. The greatest change was in prescribing patterns for females aged 85+. Dramatic increases were observed in the prescribing of preventive medications, such as those to prevent osteoporosis (+2,347%) and lipid-lowering agents (+697%). And lastly, the number of unique classes of medications prescribed to older persons has increased, with the proportion of older patients prescribed more than 10 classes of medications almost tripling during the study period.

CONCLUSIONS

Prescribing to older adults by family physicians increased substantially during the study period. This raises important concerns regarding quality of care, patient safety, and cost sustainability. It is evident that further research is urgently needed on the health outcomes (both beneficial and harmful) associated with these dramatic increases in prescribing rates.

摘要

背景

发达国家正在经历人口结构转变,老年人口数量增加,慢性病发病率上升。大多数老年人护理工作由初级保健医生提供,他们为这些患者开了大多数药物。尽管存在这些显著趋势,但对于为 65 岁以上的初级保健患者开处方的人群水平模式知之甚少。

方法

我们进行了一项基于人群的回顾性队列研究,以检查加拿大安大略省为 65 岁以上患者提供护理的家庭医生的 10 年处方趋势。

结果

在 10 年的研究期间,处方数量和处方率(即每人的处方数量)都急剧增加。变化最大的是 85 岁以上女性的处方模式。预防药物的处方明显增加,如预防骨质疏松症的药物(增加 2347%)和降脂药物(增加 697%)。最后,为老年人开的药物种类有所增加,在研究期间,开 10 种以上药物的老年患者比例几乎增加了两倍。

结论

在研究期间,家庭医生为老年人的开处方数量大幅增加。这引起了人们对医疗质量、患者安全和成本可持续性的严重关注。显然,迫切需要进一步研究与这些处方率急剧上升相关的健康结果(有益和有害)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1c3/2958963/2fb4763c4116/1471-2296-11-75-1.jpg

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