[卡铂与顺铂联合依托泊苷及卡铂联合依托泊苷治疗小细胞肺癌的比较。]

[Comparison between carboplatin and cisplatin plus etoposide and carboplatin plus etoposide in the treatment of small cell lung cancer.].

作者信息

Ren L, Hou M, Yi C, Luo D, Qiu M, Xie M, Mei Z

机构信息

Department of Medical Oncology , Cancer Center , The First University Hospital , West China University of Medical Sciences , Chengdu 610041 , P. R. China.

出版信息

Zhongguo Fei Ai Za Zhi. 1999 Dec 25;2(2):87-9. doi: 10.3779/j.issn.1009-3419.1999.02.08.

DOI:10.3779/j.issn.1009-3419.1999.02.08

PMID:20929637

Abstract

BACKGROUND

To evaluate the effect and toxicity of combination chemotherapy with carboplatin and cisplatin plus etoposide (CPE regimen) and carboplatin plus etoposide (CE regimen) in the treatment of small cell lung cancer (SCLC) .

METHODS

Thirty-two patients with SCLC were treated with CPE and CE regimens , and each regimen had 16 cases respectively. There were 10 retreated cases in CPE group and 7 retreated cases in CE group.

RESULTS

The total response rate (CR + PR) was 81. 3 %(13/ 16) in CPE group , and 87. 5 %(14/ 16) in CE group ( P > 0. 05) respectively. The response rate of the retreated cases in CPE group was 60 %(6/ 10) , and 42. 9 %(3/ 7) in CE group ( P < 0. 05) . The bone marrow suppression rate was 71. 9 % in CPE group and 93. 8 % in CE group ( P < 0. 05) . There were no significant differences between other toxicity in both groups ( P > 0. 05) .

CONCLUSIONS

The therapeutic effect of CPE regimen in SCLC is similar to that of CE regimen , but the bone marrow suppression rate of CPE regimen is less severe than that of CE regimen. The therapeutic effect of CPE regimen is better than that of CE regimen for the retreated cases.

摘要

背景

评估卡铂、顺铂联合依托泊苷（CPE方案）及卡铂联合依托泊苷（CE方案）的联合化疗方案治疗小细胞肺癌（SCLC）的疗效及毒性。

方法

32例SCLC患者分别接受CPE方案和CE方案治疗，每组各16例。CPE组有10例复治患者，CE组有7例复治患者。

结果

CPE组总缓解率（CR + PR）为81.3%（13/16），CE组为87.5%（14/16）（P > 0.05）。CPE组复治患者的缓解率为60%（6/10），CE组为42.9%（3/7）（P < 0.05）。CPE组骨髓抑制率为71.9%，CE组为93.8%（P < 0.05）。两组其他毒性反应无显著差异（P > 0.05）。