Mancia G
Cattedra di Semeiotica Medica, Università di Milano, Centro Auxologico Italiano, Italy.
Drugs. 1990;40 Suppl 4:14-20; discussion 28-30. doi: 10.2165/00003495-199000404-00005.
This paper reviews the evidence that the antihypertensive effect of urapidil is due to a systemic vasodilatation with no change in cardiac output, no tachycardia and no under-perfusion of vital organs. Urapidil does not impair the cardiovascular control exerted by arterial baroreceptors and cardiopulmonary receptors. This is probably the reason why no orthostatic hypotension and derangement in blood pressure homeostasis follows its administration.
本文综述了有关证据，表明乌拉地尔的降压作用是由于全身性血管舒张，心输出量无变化，无心动过速，重要器官无灌注不足。乌拉地尔不损害动脉压力感受器和心肺感受器对心血管的控制。这可能就是其用药后不出现体位性低血压和血压稳态紊乱的原因。
