Tsuda K, Tsuda S, Goldstein M, Masuyama Y
Neurochemistry Research Laboratories, New York University Medical Center, NY 10016.
Eur J Pharmacol. 1990 Nov 20;191(1):101-5. doi: 10.1016/0014-2999(90)94102-4.
We now describe the effects of calcitonin gene-related peptide (CGRP) on [3H]norepinephrine (NE) release in medulla oblongata of spontaneously hypertensive rats (SHR). CGRP inhibited stimulation-evoked [3H]NE release in a dose-dependent manner in Sprague-Dawley rats, although the basal release of [3H]NE was not affected by the peptide. In SHR, the inhibitory effect of CGRP on stimulation-evoked [3H]NE release was significantly attenuated compared with Wistar Kyoto rats. These results suggest that CGRP might be involved in the regulation of central sympathetic nervous activity in hypertension.
我们现在描述降钙素基因相关肽（CGRP）对自发性高血压大鼠（SHR）延髓中[3H]去甲肾上腺素（NE）释放的影响。在Sprague-Dawley大鼠中，CGRP以剂量依赖的方式抑制刺激诱发的[3H]NE释放，尽管该肽对[3H]NE的基础释放没有影响。在SHR中，与Wistar Kyoto大鼠相比，CGRP对刺激诱发的[3H]NE释放的抑制作用明显减弱。这些结果表明，CGRP可能参与高血压中枢交感神经活动的调节。
