Department of Dermatology, University of North Carolina-Chapel Hill School of Medicine, Chapel Hill, NC, USA.
G Ital Dermatol Venereol. 2010 Oct;145(5):675-87.
Pemphigus is a family of human autoimmune blistering diseases in which pathogenic autoantibodies induce blistering in skin and mucosa. The mechanisms by which pemphigus autoantibodies induce disease in the skin is under active investigation. A large number of cellular events induced in the target keratinocytes by pemphigus IgG have been described and suggest that pemphigus IgG binding to desmogleins trigger a complicated cascade of intracellular signaling and regulatory events. Targeting these intracellular events may prove useful therapeutically.
天疱疮是一组人类自身免疫性水疱病，其中致病性自身抗体诱导皮肤和黏膜水疱。天疱疮自身抗体在皮肤中诱导疾病的机制正在积极研究中。大量已描述的天疱疮 IgG 诱导靶角朊细胞中的细胞事件表明，天疱疮 IgG 与桥粒芯糖蛋白的结合引发了复杂的细胞内信号和调节事件级联。针对这些细胞内事件可能具有治疗意义。
