深入探究后果：JAK抑制剂在癌症中抑制STAT3 - Suppr | 超能文献

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Peering into the aftermath: JAKi rips STAT3 in cancer.深入探究后果：JAK抑制剂在癌症中抑制STAT3

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Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways.从山苍子中分离得到的去甲乌药碱和网状番荔枝碱通过JAK2/STAT3和NF-κB信号通路发挥抗炎作用。

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Targeting the JAK2/STAT3 Pathway-Can We Compare It to the Two Faces of the God Janus?靶向 JAK2/STAT3 通路——我们可以将其比作两面神雅努斯吗？

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Sodium butyrate relieves lung ischemia-reperfusion injury by inhibiting NF-κB and JAK2/STAT3 signaling pathways.丁酸钠通过抑制 NF-κB 和 JAK2/STAT3 信号通路缓解肺缺血再灌注损伤。

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Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis.长链非编码 RNA DILC 通过 IL-6/STAT3 轴调控肝癌干细胞。

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17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.17-羟基乔可那内酯B通过共价交联Janus激酶抑制信号转导子和转录激活子3信号通路，并诱导人癌细胞凋亡。

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IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis.IKK/NF-κB 和 STAT3 信号通路：炎症介导的肿瘤促进和转移中的中央信号枢纽。

EMBO Rep. 2009 Dec;10(12):1314-9. doi: 10.1038/embor.2009.243. Epub 2009 Nov 6.

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JAK2 inhibitor blocks the inflammation and growth of esophageal squamous cell carcinoma in vitro through the JAK/STAT3 pathway.JAK2抑制剂通过JAK/STAT3信号通路在体外阻断食管鳞状细胞癌的炎症反应和生长。

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Stachydrine ameliorates isoproterenol-induced cardiac hypertrophy and fibrosis by suppressing inflammation and oxidative stress through inhibiting NF-κB and JAK/STAT signaling pathways in rats.水苏碱通过抑制大鼠体内的NF-κB和JAK/STAT信号通路来抑制炎症和氧化应激，从而改善异丙肾上腺素诱导的心脏肥大和纤维化。

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Methylseleninic Acid Suppresses Breast Cancer Growth via the JAK2/STAT3 Pathway.甲基亚硒酸通过JAK2/STAT3信号通路抑制乳腺癌生长。

Reprod Sci. 2019 Jun;26(6):829-838. doi: 10.1177/1933719118815582. Epub 2018 Dec 9.

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Second-Generation Jak2 Inhibitors for Advanced Prostate Cancer: Are We Ready for Clinical Development?用于晚期前列腺癌的第二代Jak2抑制剂：我们准备好进行临床开发了吗？

Cancers (Basel). 2021 Oct 17;13(20):5204. doi: 10.3390/cancers13205204.

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Overexpression of a Long Non-Coding RNA BC037916 is Associated with Pancreatic Tumorigenesis and Poor Prognosis.长链非编码RNA BC037916的过表达与胰腺肿瘤发生及不良预后相关。

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本文引用的文献

1

Immunity, inflammation, and cancer.免疫、炎症与癌症。

Cell. 2010 Mar 19;140(6):883-99. doi: 10.1016/j.cell.2010.01.025.

2

The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors.JAK2抑制剂AZD1480可有效阻断实体瘤中的Stat3信号传导和肿瘤发生。

Cancer Cell. 2009 Dec 8;16(6):487-97. doi: 10.1016/j.ccr.2009.10.015.

3

IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis.IKK/NF-κB 和 STAT3 信号通路：炎症介导的肿瘤促进和转移中的中央信号枢纽。