Mihas A A, Ceballos R, Mihas T A, Hirschowitz B I
Division of Digestive Diseases, University of Mississippi, Jackson 39216.
J Med. 1990;21(6):301-11.
We have investigated the effects of polymyxin B and gentamicin on the histologic and biochemical alterations caused by D-galactosamine in the rat. Polymyxin B, but not gentamicin, protected against galactosamine-induced liver injury. There was good correlation between the biochemical data and the morphologic changes. This study suggests that endogenously produced endotoxin contributes to the extent of the hepatic damage caused by galactosamine. It is likely that the ability of the liver to detoxify small amounts of bacterial lipopolysaccharides absorbed from the gut is impaired after the preceding galactosamine injury.
我们研究了多粘菌素B和庆大霉素对大鼠D-半乳糖胺所致组织学和生化改变的影响。多粘菌素B可预防半乳糖胺诱导的肝损伤，而庆大霉素则不能。生化数据与形态学变化之间存在良好的相关性。本研究提示，内源性产生的内毒素在半乳糖胺所致肝损伤程度中起作用。很可能在先前的半乳糖胺损伤后，肝脏解毒从肠道吸收的少量细菌脂多糖的能力受损。
