University of Exeter, Exeter, UK.
Eur Eat Disord Rev. 2011 Jan-Feb;19(1):55-8. doi: 10.1002/erv.1047.
Previous studies have demonstrated localised abnormalities of cerebral blood flow in anorexia nervosa, suggesting reduction of cerebral activity and function in specific regions. There is debate as to whether such findings are secondary to starvation or indicative of a primary abnormality predating the illness, representing an underlying biological substrate. This small study, the first in early onset anorexia nervosa, reports findings of regional cerebral blood flow (rCBF) at both baseline and follow up.
Nine participants who had previously undergone rCBF studies at the start of treatment, had a repeat scan at an average of 4.2 years later.
Seven out of the nine had persisting reduced cerebral blood flow in one area of the brain, predominantly the medial temporal region.
These data suggest that in the majority of cases rCBF does not return to normal following weight restoration. The implications for future research are explored.
先前的研究表明神经性厌食症患者存在局部脑血流异常，这表明特定区域的大脑活动和功能减少。目前存在争议的是，这些发现是由饥饿引起的，还是表明疾病发生前存在原发性异常，代表潜在的生物学基础。这项小型研究是对早期发病的神经性厌食症的首次研究，报告了基线和随访时局部脑血流（rCBF）的发现。
9 名参与者在治疗开始时接受了 rCBF 研究，平均在 4.2 年后进行了重复扫描。
9 名参与者中有 7 名在大脑的一个区域（主要是内侧颞区）持续存在脑血流减少。
这些数据表明，在大多数情况下，体重恢复后 rCBF 不会恢复正常。探讨了对未来研究的影响。
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