儿童期起病的神经性厌食症：迈向确定生物学基础
Childhood-onset anorexia nervosa: towards identifying a biological substrate.
作者信息
Gordon I, Lask B, Bryant-Waugh R, Christie D, Timimi S
机构信息
Department of Radiology, Great Ormond Street Hospital for Children, London, United Kingdom.
出版信息
Int J Eat Disord. 1997 Sep;22(2):159-65. doi: 10.1002/(sici)1098-108x(199709)22:2<159::aid-eat7>3.0.co;2-e.
OBJECTIVE
The etiology of anorexia nervosa is not fully understood, but is probably multifactorial, including a biological substrate. The purpose of this paper is to investigate the possible underlying biological substrate.
METHOD
Fifteen children and adolescents aged 8-16 years underwent regional cerebral blood blow radioisotope scans. All fulfilled DSM-IV criteria for anorexia nervosa. Three of the girls had a follow-up scan when they had regained their lost weight.
RESULTS
Thirteen of the 15 patients had unilateral temporal lobe hypoperfusion, 8 on the left side and 5 on the right. The abnormality persisted in the 3 girls who had a follow-up scan after weight restoration.
DISCUSSION
This is the first report of reduced regional cerebral blood flow in childhood-onset anorexia nervosa, and suggests an underlying primary functional abnormality.
目的
神经性厌食症的病因尚未完全明确，但可能是多因素的，包括生物学基础。本文旨在研究可能存在的潜在生物学基础。
方法
15名8至16岁的儿童和青少年接受了局部脑血流放射性同位素扫描。所有患者均符合神经性厌食症的DSM-IV标准。其中3名女孩在体重恢复后进行了随访扫描。
结果
15名患者中有13名存在单侧颞叶灌注不足，左侧8例，右侧5例。体重恢复后进行随访扫描的3名女孩中，这种异常情况持续存在。
讨论
这是关于儿童期起病的神经性厌食症局部脑血流减少的首次报道，提示存在潜在的原发性功能异常。
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