Biomedical Engineering and Emergency Medicine, University of Virginia Health System, Charlottesville, VA, USA.
J Environ Pathol Toxicol Oncol. 2010;29(2):85-9. doi: 10.1615/jenvironpatholtoxicoloncol.v29.i2.20.
Vitamin D deficiency has bee associated with bone diseases, cardiovascular diseases, cancer, and multiple sclerosis. Recent clinical studies have pointed out that these diseases could be prevented by either adequate sun exposure or oral vitamin D3 supplementation. In an effort to prevent these illnesses, emergency physicians and other clinicians must be aware of technological advances in the measurement of serum concentrations of 25-hydroxyvitamin D. Realizing the importance of diagnosing vitamin D deficiency, we reviewed the following advanced diagnostic techniques: liquid chromatography tandem mass spectrometry, radioimmunoassay, and DiaSorin's immunochemiluminometric automated analyzer LIASION®. On the basis of this review, we have found that each of these diagnostic tests has documented limitations, and therefore we recommend an international standardization of these assays to accurately diagnose vitamin D deficiency.
维生素 D 缺乏与骨骼疾病、心血管疾病、癌症和多发性硬化症有关。最近的临床研究指出，这些疾病可以通过充足的阳光暴露或口服维生素 D3 补充来预防。为了预防这些疾病，急诊医生和其他临床医生必须了解血清 25-羟维生素 D 浓度测量的技术进展。鉴于诊断维生素 D 缺乏的重要性，我们回顾了以下先进的诊断技术：液相色谱串联质谱法、放射免疫分析法和 DiaSorin 的免疫化学发光自动分析仪 LIASION®。基于这项回顾，我们发现这些诊断检测都存在有记录的局限性，因此我们建议对这些检测进行国际标准化，以准确诊断维生素 D 缺乏症。
