犬 P4 型 ATP 酶 ATP10C 的 mRNA 表达与体况评分呈正相关。

mRNA expression of canine ATP10C, a P4-type ATPase, is positively associated with body condition score.

机构信息

Department of Large Animal Clinical Sciences, University of Tennessee, Knoxville, TN 37996, USA.

出版信息

Vet J. 2011 Oct;190(1):173-5. doi: 10.1016/j.tvjl.2010.09.008. Epub 2010 Oct 6.

DOI:10.1016/j.tvjl.2010.09.008

PMID:20932785

Abstract

Mouse and human Atp10c genes are strong candidates for changes in bodyweight and glucose homeostasis. Using comparative genomic analysis, a novel canine P4-type ATPase, ATP10C, was identified. Expression of ATP10C was compared between sex-matched lean (body condition score, BCS<8; n=7) and obese (BCS⩾8, n=8) client-owned dogs of comparable ages. Canine ATP10C is highly expressed in visceral and subcutaneous fat at approximately 3-fold levels compared to the omental adipose depot. There was a 5-fold significant increase (P<0.0001) in mRNA expression of ATP10C in dogs with a BCS⩾8.

摘要

鼠和人 Atp10c 基因是体重和葡萄糖稳态变化的强候选基因。利用比较基因组分析，鉴定出一种新型犬 P4 型 ATP 酶，ATP10C。在年龄相当的配对瘦（体况评分，BCS<8；n=7）和肥胖（BCS ⩾8，n=8）客户犬之间比较 ATP10C 的表达。犬 ATP10C 在内脏和皮下脂肪中的表达水平大约是大网膜脂肪库的 3 倍。BCS ⩾8 的犬的 ATP10CmRNA 表达显著增加 5 倍（P<0.0001）。