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[肾上腺嗜铬细胞瘤。诊断与治疗的现状]

[Adrenal pheochromocytoma. Current aspects of diagnosis and treatment].

作者信息

Sassine A M, Lamy S, Lorang C, Capesius C

机构信息

Service d'Urologie Centre Hospitalier de Luxembourg.

出版信息

Acta Urol Belg. 1990;58(4):71-81.

PMID:2093300
Abstract

Since 1984, 5 patients with pheochromocytoma were operated in our department. Diagnosis was suspected by clinical findings and symptoms, and confirmed by measuring catecholamines and metabolites in 24 hours urine specimen. CT Scan located all the tumors. Iodine 131-MIBG confirmed the diagnosis and the location since it was used for the last three cases. Patients were prepared with alpha-blockade with or without beta-blockade. Volume expansion and monitoring with Swan-Ganz catheter was performed 24 hours before the operation. The surgical approaches were: anterior trans-abdominal once, thoraco-abdominal twice, and retro-peritoneal twice with less morbidity. We propose the following attitude when pheochromocytoma is suspected: 1. 24 hours urine catecholamines and metabolites, 2. CT-Scan and RMN if available, 3. Iodine 131-MIBG scintigraphy, 4. Pre-operative alpha-blockade associated with beta-blockade if necessary, 5. Retro-peritoneal approach for the uni-lateral adrenal pheochromocytoma.

摘要

自1984年以来,我科共为5例嗜铬细胞瘤患者实施了手术。通过临床表现和症状怀疑诊断,并通过检测24小时尿标本中的儿茶酚胺及其代谢产物得以确诊。CT扫描确定了所有肿瘤的位置。碘131-间碘苄胍(Iodine 131-MIBG)用于最后3例患者,从而进一步明确了诊断和肿瘤位置。患者术前接受了α-阻滞剂治疗,部分患者联合使用了β-阻滞剂。术前24小时进行了扩容,并使用Swan-Ganz导管进行监测。手术入路包括:经腹前路1次,胸腹联合入路2次,腹膜后入路2次,后者并发症较少。当怀疑嗜铬细胞瘤时,我们建议采取以下措施:1. 检测24小时尿儿茶酚胺及其代谢产物;2. 如有条件,进行CT扫描和磁共振成像(RMN);3. 碘131-MIBG闪烁显像;4. 必要时术前联合使用α-阻滞剂和β-阻滞剂;5. 对于单侧肾上腺嗜铬细胞瘤,采用腹膜后入路。

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