胎儿宫内生长异常与精神分裂症风险：芬兰北部 1966 年出生队列的 34 年随访研究。
Deviant intrauterine growth and risk of schizophrenia: a 34-year follow-up of the Northern Finland 1966 Birth Cohort.
机构信息
Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, PO Box 5000, FIN-90014 Oulu, Finland.
出版信息
Schizophr Res. 2010 Dec;124(1-3):223-30. doi: 10.1016/j.schres.2010.09.006. Epub 2010 Oct 8.
BACKGROUND
Low birth weight conveys a modest risk for schizophrenia. The effects of high birth weight and deviant birth length are less clear.
METHODS
We linked perinatal data from 10,934 subjects from the Northern Finland 1966 Birth Cohort (n = 12 058) to the Finnish Hospital Discharge Register where we identified 111 cases of DSM-III-R schizophrenia up to age 35 years. Adjusted odds ratios between the risk of schizophrenia and birth weight, birth length and ponderal index and the risk of schizophrenia were analyzed.
RESULTS
Both low (OR 2.5; 95% CI 1.2-5.1) and high birth weight (OR 2.4; 95% CI 1.1-4.9) increased the risk of later schizophrenia. In addition, short (OR 2.6; 95% CI 1.1-5.9) and long babies had an elevated risk of schizophrenia as adults (OR 1.8; 95% CI 1.0-3.5). A reverse J-shape curve described the associations between birth weight, length and schizophrenia.
CONCLUSIONS
Deviant intrauterine growth of the fetus in either direction was associated with increased risk of schizophrenia.
背景
低出生体重与精神分裂症的风险呈中度相关。高出生体重和出生体长异常的影响尚不明确。
方法
我们将来自芬兰北部 1966 年出生队列（n = 12058）的 10934 名受试者的围产期数据与芬兰住院记录进行了关联，我们在其中确定了 111 例 DSM-III-R 精神分裂症病例，年龄在 35 岁以下。分析了出生体重、出生体长和体重指数与精神分裂症风险之间的比值比（OR）。
结果
低体重（OR 2.5；95%CI 1.2-5.1）和高体重（OR 2.4；95%CI 1.1-4.9）均增加了以后患精神分裂症的风险。此外，婴儿出生体长过短（OR 2.6；95%CI 1.1-5.9）或过长（OR 1.8；95%CI 1.0-3.5）也会增加成年后患精神分裂症的风险。出生体重、体长与精神分裂症之间存在一种反向 J 形曲线关系。
结论
胎儿宫内生长的任何方向的异常都与精神分裂症风险增加有关。
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