Crook T H, Larrabee G J, Youngjohn J R
Memory Assessment Clinics, Inc., Bethesda, MD 20814.
Clin Neuropharmacol. 1990;13 Suppl 3:S81-91. doi: 10.1097/00002826-199013003-00009.
Age-associated memory impairment (AAMI) is a diagnostic term applied to healthy persons greater than 50 years of age who have experienced a gradual decline in memory that lies within the boundaries of normality. Although the behavioral deficits associated with AAMI are modest in comparison to those associated with dementing disorders such as Alzheimer's disease, they are quite troublesome to many middle-aged and elderly adults engaged in intellectually demanding activities. In this article, diagnostic criteria for AAMI will be provided, new psychometric instruments for assessing the behavioral deficits seen in AAMI will be described, and results of large multinational studies with these instruments will be presented. Finally, behavioral and pharmacologic strategies for treating AAMI will be discussed.
年龄相关性记忆减退（AAMI）是一个诊断术语，适用于年龄超过50岁、记忆功能逐渐下降但仍在正常范围内的健康人群。尽管与AAMI相关的行为缺陷与诸如阿尔茨海默病等痴呆症相关的行为缺陷相比并不严重，但对于许多从事需要智力活动的中老年人来说，这些缺陷相当麻烦。在本文中，将提供AAMI的诊断标准，描述用于评估AAMI中所见行为缺陷的新心理测量工具，并展示使用这些工具的大型跨国研究结果。最后，将讨论治疗AAMI的行为和药物策略。
