Reslová T, Donát J, Kohoutek M
Gynek.-porod. klinika LF KU, Hradec Králové.
Cesk Gynekol. 1990 Nov;55(9):645-8.
In a group of 92 postmenopausal women with climacteric and postcastration syndrome the relationship between different types of hormonal therapy and changes of indicators of the lipid metabolism was investigated. Before onset of treatment and after three weeks of treatment the authors assessed total cholesterol, beta-lipoproteins, triglycerides, HDL, LDL and plasma concentrations of oestrone and 17-beta-oestradiol. A significant rise of both oestrogens was recorded in a group treated with Presomen tablets and Folovirin inj. In the lipoprotein fractions only beta-lipoproteins rose significantly during administration of Mestranol tabl. and Provera tabl. The investigation is the beginning of a prospective study concerned with the possibility to influence one of the risk factors participating in the development of arteriosclerosis.
在一组92名患有更年期和去势后综合征的绝经后女性中，研究了不同类型激素治疗与脂质代谢指标变化之间的关系。在治疗开始前和治疗三周后，作者评估了总胆固醇、β-脂蛋白、甘油三酯、高密度脂蛋白、低密度脂蛋白以及雌酮和17-β-雌二醇的血浆浓度。在用普雷索门片和福乐维林注射液治疗的组中，两种雌激素均显著升高。在脂蛋白组分中，仅在服用炔雌醇甲醚片和安宫黄体酮片期间β-脂蛋白显著升高。该研究是一项前瞻性研究的开端，该前瞻性研究关注影响参与动脉粥样硬化发展的危险因素之一的可能性。
