α受体介导对大鼠大脑皮层突触体中3H-去甲肾上腺素释放的调节。
Alpha-receptor-mediated modulation of 3H-noradrenaline release from rat brain cortex synaptosomes.
作者信息
Mulder A H, de Langen C D, de Regt V, Hogenboom F
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1978 Jun;303(2):193-6. doi: 10.1007/BF00508068.
The effects of oxymetazoline and noradrenaline (in the presence of desipramine) on the release of 3H-noradrenaline from rat brain cortex synaptosomes were studied using a superfusion technique. Both drugs (at 1 micrometer concentrations) were found to reduce the depolarization-induced (15 mM K+) release of 3H-noradrenaline. The release-modulating effect of noradrenaline was antagonized by phentolamine and yohimbine. The data provide direct evidence for the hypothesis that alpha-receptors modulating the release of noradrenaline are localized on varicosities of central noradrenergic neurones.
采用灌流技术研究了羟甲唑啉和去甲肾上腺素（在存在地昔帕明的情况下）对大鼠脑皮质突触体中3H-去甲肾上腺素释放的影响。发现两种药物（浓度为1微摩尔）均能减少去极化诱导的（15毫摩尔钾离子）3H-去甲肾上腺素释放。酚妥拉明和育亨宾可拮抗去甲肾上腺素的释放调节作用。这些数据为以下假说提供了直接证据：调节去甲肾上腺素释放的α受体定位于中枢去甲肾上腺素能神经元的曲张体上。
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