From the Department of Developmental Biology, Washington University School of Medicine, St Louis, MO.
Cornea. 2010 Nov;29 Suppl 1:S7-12. doi: 10.1097/ICO.0b013e3181ea4714.
In our current society, achieving "productive aging," which aims to keep people as productive as possible with good health and spirit for their private and social activities as they grow older, will be important to maximize the duration of high quality of life and to promote a stable economy and solvent social security in healthcare systems. To achieve this goal, we have been studying mechanisms of mammalian aging and longevity, focusing on the physiological importance of the mammalian nicotinamide adenine dinucleotide (NAD)--dependent protein deacetylase SIRT1 and systemic NAD biosynthesis mediated by nicotinamide phosphoribosyltransferase for the regulation of metabolism and aging. Through these studies, we have recently proposed a comprehensive concept of a novel systemic regulatory network for metabolism and aging, named "NAD World." This new concept of NAD World also conveys ideas of functional hierarchy and frailty for the induction of aging in mammals. Details of the NAD World and its implications to age-associated metabolic diseases such as type 2 diabetes will be discussed.
在当今社会，实现“生产性老龄化”至关重要，其目标是让人们在保持健康和精神状态良好的情况下尽可能长时间地参与私人和社会活动，以最大化高质量生活的持续时间，并促进经济稳定和有支付能力的医疗保健系统的社会保障。为了实现这一目标，我们一直在研究哺乳动物衰老和长寿的机制，重点研究哺乳动物烟酰胺腺嘌呤二核苷酸（NAD）依赖性蛋白去乙酰化酶 SIRT1 和烟酰胺磷酸核糖基转移酶介导的系统性 NAD 生物合成的生理重要性，以调节代谢和衰老。通过这些研究，我们最近提出了一个用于代谢和衰老的新型系统性调节网络的综合概念，称为“NAD 世界”。NAD 世界的新概念也传达了哺乳动物衰老诱导的功能层次结构和脆弱性的思想。将讨论 NAD 世界的细节及其对 2 型糖尿病等与年龄相关的代谢疾病的影响。
