[Mechanisms of carbapenems resistance in acinetobacter and progress of treatment].
作者信息
Zhang Wei, Liu Kai-Zhong
机构信息
Intensive Care Unit, Zhejiang Cancer Hospital, Hangzhou 310022, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Sep;39(5):542-7. doi: 10.3785/j.issn.1008-9292.2010.05.017.
Abstract
Acinetobacter has been the major pathogen of nosocomial infection. With the wide use of carbapenems, the emergence of multi-resistant isolates especially those resistant to carbapenem, brings a great problem to clinical treatment. The production of inactive enzymes is the main mechanism for antibiotic resistance, particularly the production of carbapenemases mediated by chromosome or plasmid. Combinations of β-lactam antibiotics and sulbactam may show synergism or partial synergism for acinetobacter isolates.
摘要
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