Kyoto Pharmaceutical University,Yamashina, Kyoto 607-8412, Japan.
Org Lett. 2010 Nov 5;12(21):4788-91. doi: 10.1021/ol1019376.
Gold(I)-catalyzed asymmetric cyclization of 1,3-dihydroxymethyl-2-alkynylbenzene chromium complexes gave planar chiral isochromene chromium complexes with high enantioselectivity. Enantiomeric excess of the cyclization products was largely affected by a combination of axially chiral diphosphine(AuCl)(2) precatalysts and silver salts. A system of segphos(AuCl)(2) with AgBF(4) resulted in the formation of the corresponding antipode.
金（I）催化的 1,3-二羟甲基-2-炔基苯铬配合物的不对称环化反应得到了具有高对映选择性的平面手性异色烯铬配合物。环化产物的对映过量主要受到轴手性双膦（AuCl）（2）前催化剂和银盐的组合影响。Segphos（AuCl）（2）与 AgBF（4）的体系导致相应对映异构体的形成。
