Yamakado T, Fukui A, Kato N, Murayama S, Ookubo S, Hayashi T, Mori S, Futagami Y, Hamada M, Nakano T
First Department of Internal Medicine, Mie University, Tsu, Japan.
Heart Vessels Suppl. 1990;5:80-3.
To assess left ventricular (LV) diastolic function in idiopathic restrictive cardiomyopathy (IRCM) and amyloid restrictive cardiomyopathy (ARCM), we analyzed LV cineangiograms and pressures (tip manometer) in two patients, one with IRCM and the other with ARCM. LV volume and instantaneous rate of change of volume were derived from frame-by-frame analyses of angiograms. LV relaxation was assessed by the time constant of isovolumic pressure decay. LV compliance was evaluated by the pressure-volume relationship. From these analyses, we conclude as follows: (1) In restrictive cardiomyopathy (RCM), LV diastolic dysfunction may be characterized by impaired relaxation and decreased compliance; (2) LV diastolic filling was minimally impaired or normal in both conditions; (3) The ventricular diastolic pressure wave form of "dip and plateau" seemed not to be a characteristic sign in RCM.
为评估特发性限制型心肌病（IRCM）和淀粉样变限制型心肌病（ARCM）的左心室（LV）舒张功能，我们分析了两名患者的左心室血管造影片和压力（顶端压力计），其中一名患有IRCM，另一名患有ARCM。左心室容积和容积的瞬时变化率通过血管造影片的逐帧分析得出。左心室舒张功能通过等容压力衰减的时间常数进行评估。左心室顺应性通过压力-容积关系进行评价。通过这些分析，我们得出以下结论：（1）在限制型心肌病（RCM）中，左心室舒张功能障碍可能表现为舒张功能受损和顺应性降低；（2）在这两种情况下，左心室舒张期充盈仅有轻微受损或正常；（3）“下陷和高原”型心室舒张压波形似乎不是RCM的特征性表现。
