Bondy G P, Okey A B
Oncology. 1978;35(3):127-31. doi: 10.1159/000225270.
Substrains of C3H mice, with and without the milk-transmitted form of the mouse mammary tumor virus (MMTV)1, were compared to determine if the presence of MMTV altered estrogen action. Uterine weight response to oral diethylstilbestrol was the same for both substrains, (MMTV+ and MMTV-). The concentration of high-affinity estrogen binding sites ("receptors") in lactating mammary tissue did not differ significantly for MMTV+ versus MMTV- mice; the affinity of the estradiol-receptor interaction appeared higher, however, in cytosol from MMTV- mice. Sucrose density gradient analysis revealed no significant differences in sedimentation properties of cytosol receptor from the two substrains.
对携带和不携带通过乳汁传播形式的小鼠乳腺肿瘤病毒（MMTV）的C3H小鼠亚系进行了比较，以确定MMTV的存在是否改变雌激素作用。两个亚系（MMTV+和MMTV-）对口服己烯雌酚的子宫重量反应相同。MMTV+小鼠与MMTV-小鼠的泌乳乳腺组织中高亲和力雌激素结合位点（“受体”）浓度无显著差异；然而，MMTV-小鼠胞质溶胶中雌二醇-受体相互作用的亲和力似乎更高。蔗糖密度梯度分析显示，两个亚系的胞质溶胶受体沉降特性无显著差异。
