神经元 Nogo-A 敲低后新生皮层锥体神经元树突棘的改变。
Dendritic spine alterations in neocortical pyramidal neurons following postnatal neuronal Nogo-A knockdown.
机构信息
Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, Ill., USA.
出版信息
Dev Neurosci. 2010;32(4):313-20. doi: 10.1159/000309135. Epub 2010 Oct 13.
Abstract
The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells.
摘要
少突胶质细胞髓鞘相关蛋白 Nogo-A 是一种众所周知的轴突再生和代偿性可塑性抑制剂，但神经元 Nogo-A 的功能尚不清楚。本研究探讨了神经元 Nogo-A 水平降低对发育中的大脑皮质神经元树突棘的影响。这些神经元中 Nogo-A 水平的降低导致树突棘密度降低和丝状伪足样突起增加。这些结果表明神经元 Nogo-A 在维持大脑皮质锥体神经元的棘突表型中起作用。
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