Weindorf N, Schultz-Ehrenburg U
Dermatologische Universitätsklinik, St Josef-Hospital Ruhr-Universität, Bochum.
Phlebologie. 1990 Nov-Dec;43(4):573-7.
The aim of the present prospective epidemiological study was to find the genesis of varicosis in pupils of the same age group in 11 secondary schools of the town of Bochum. The studies were always carried out in the same pupils of the 5th, 9th and 13th grades (Bochum studies I, II, III). The results of the first and second studies on 518 pupils are compared. In the children aged between 10 and 12 years of Bochum study I, isolated refluxes were found at the saphenofemoral junction (internal saphenous vein 2.9%, external saphenous vein 0.2%), but no varicose vein was yet visible at the trunk level or that of the lateral branches. In the adolescents aged between 14 and 16 years of Bochum study II, the number of refluxes of the internal and external saphenous vein had greatly increased, and isolated varicose veins were found at the trunk level or that of the lateral branches, as well as insufficient perforating veins. The varicose veins visible at the trunk level are obviously preceded by the refluxes. For the first time, an easily detectable preclinical sign offering new perspectives for a primary prophylaxis in thus available. Discrete reticular varicose veins were already found in Bochum study I (10.2%). A photoplethysmographic discrimination between the normal results and the various forms of a starting varicosis revealed in the course of Bochum study II has not been possible. Up to now, no statistical proof of a family taint has been established.
本前瞻性流行病学研究的目的是探寻波鸿市11所中学同一年龄组学生静脉曲张的成因。研究总是针对五年级、九年级和十三年级的同一批学生进行（波鸿研究I、II、III）。对518名学生的首次和第二次研究结果进行了比较。在波鸿研究I中10至12岁的儿童中，在隐股交界处发现了孤立性反流（大隐静脉2.9%，小隐静脉0.2%），但在主干或侧支水平尚未可见静脉曲张。在波鸿研究II中14至16岁的青少年中，大隐静脉和小隐静脉的反流数量大幅增加，在主干或侧支水平发现了孤立性静脉曲张以及功能不全的穿通静脉。主干水平可见的静脉曲张显然先有反流。首次出现了一种易于检测的临床前体征，为一级预防提供了新的视角。在波鸿研究I中已经发现了离散的网状静脉曲张（10.2%）。在波鸿研究II过程中，用光电容积描记法区分正常结果和各种形式的早期静脉曲张是不可能的。到目前为止，尚未确立家族遗传倾向的统计学证据。
