Saugier B, Brunat M, Cordier J F, Gerard J P, Dorsit G, Marchandise J F, Bastidon R, Perol M, Brune J, Galy P
Nouv Presse Med. 1978 Apr 22;7(16):1357-61.
A cyclic and sequential combination of adriamycin, vincristine (or VM 26) and cyclophosphamide was used, with a follow up of 4 to 33 months in 38 patients with a "micro-cellular" carcinoma of the lung. Radiotherapy was used in association in a variable manner. Chemotherapy alone resulted in marked regression of the lesions (regression is greater than 50%) in approximately 65 per cent of cases and a level of complete regression which varied from 31 to 45 per cent according to the degree of diffusion of the lesions at the time of admission. In this study, survival in apparently localised forms was 70 per cent after one year and 55 per cent at eighteen months, whilst it was 34 per cent at one year and nil at eighteen months in patients with evidence of metastatic disease at the time of entry. These encouraging results indicate a hope for improvement, in certain patients reacting favourably to this protocol, in the still grave prognosis of "small cell" carcinoma of the lung.
采用阿霉素、长春新碱（或威猛）和环磷酰胺进行周期性序贯联合治疗，对38例肺“微细胞”癌患者进行了4至33个月的随访。放疗以不同方式联合使用。单纯化疗使约65%的病例出现明显的病变消退（消退率大于50%），完全消退率根据入院时病变的扩散程度在31%至45%之间变化。在本研究中，明显局限性病例的1年生存率为70%，18个月时为55%，而入院时有转移证据的患者1年生存率为34%，18个月时为零。这些令人鼓舞的结果表明，对于某些对该方案反应良好的患者，在肺癌“小细胞”癌预后仍然严重的情况下，有望得到改善。
