Division of Geriatrics, University of California, San Francisco, and the San Francisco VA Medical Center, San Francisco, California 94121, USA.
JAMA. 2010 Oct 13;304(14):1592-601. doi: 10.1001/jama.2010.1482.
Multiple medication use is common in older adults and may ameliorate symptoms, improve and extend quality of life, and occasionally cure disease. Unfortunately, multiple medication use is also a major risk factor for prescribing and adherence problems, adverse drug events, and other adverse health outcomes. Using the case of an older patient taking multiple medications, this article summarizes the evidence-based literature about improving medication use and withdrawing specific drugs and drug classes. It also describes a systematic approach for how health professionals can assess and improve medication regimens to benefit patients and their caregivers and families.
老年人普遍存在多重用药的情况，多重用药可以改善症状、提高并延长生活质量，偶尔还能治愈疾病。但不幸的是，多重用药也是导致处方和用药依从性问题、药物不良事件和其他不良健康后果的一个主要危险因素。本文通过一位正在服用多种药物的老年患者的案例，对改善用药和停用特定药物和药物类别的循证文献进行了总结。还描述了一种系统的方法，供卫生专业人员评估和改善用药方案，使患者及其护理人员和家属受益。
