Karsay K
Department of Obstetrics and Gynaecology, Municipal Hospital Outpatient Clinic, Karcag.
Ther Hung. 1990;38(4):181-5.
The relationship between migraineous headaches and the use of low-dose oral contraceptives, the monophasic Rigevidon and the biphasic Anteovin, has been examined. In the examined cases Anteovin of higher oestrogen content provoked more vascular cephalalgias than Rigevidon with it's lower oestrogen content. In one part of the cases both pills even had therapeutic effects. According to the opinion of the author classical migraine means a relative contra-indication of hormonal contraception and is a serious adverse effect requiring the discontinuance of oral contraception. The headaches develop during the adaptational period of oral contraception and the migraineous attacks occur in the premenstrual period or at the beginning of menstruation which refer to an oestrogen withdrawal character. It may be supposed that vasoconstriction of certain extent, which has existed during the use of the pills, changes over to relative vasodilatation in this period and the extent of the changes is dependent on the oestreogen content of the tablets.
已对偏头痛性头痛与使用低剂量口服避孕药（单相的妈富隆和双相的复方炔诺孕酮）之间的关系进行了研究。在所检查的病例中，雌激素含量较高的复方炔诺孕酮比雌激素含量较低的妈富隆引发更多的血管性头痛。在一部分病例中，两种药丸甚至都有治疗效果。根据作者的观点，典型偏头痛意味着激素避孕的相对禁忌证，是一种需要停用口服避孕药的严重不良反应。头痛在口服避孕药的适应期出现，偏头痛发作发生在经前期或月经开始时，这表明具有雌激素撤退特征。可以推测，在服用避孕药期间存在的一定程度的血管收缩在此期间转变为相对血管扩张，且变化程度取决于片剂中的雌激素含量。
