van Boekel V, Godoy J M, Menezes J M
Unidade de Terapia Intensiva do Hospital de Ipanema, Rio de Janeiro, Brasil.
Arq Neuropsiquiatr. 1990 Dec;48(4):505-14. doi: 10.1590/s0004-282x1990000400018.
Based on the inexistence of references in Brazilian and International literature of the association polymyositis, myasthenia gravis and thymoma in a young male adult, the authors propose to describe one case presenting the associated syndrome. The disease began when the patient was 22 years old, being the climax of its clinical expression four years later. It is emphasized the difficulty on the differential diagnosis between polymyositis and myasthenia gravis, once these diseases frequently have their clinical manifestations well individualized. In this study we call attention to the existence of clinical aspects of myasthenia gravis in patients presenting polymyositis and, on the other hand, histopathological alterations typical of polymyositis in myasthenic muscles, what makes the clinical diagnosis uncertain many times.
鉴于巴西和国际文献中不存在关于年轻成年男性患多发性肌炎、重症肌无力和胸腺瘤综合征的相关记载，作者在此描述一例呈现该相关综合征的病例。该疾病始于患者22岁时，四年后达到临床症状的高峰。需要强调的是，多发性肌炎和重症肌无力的鉴别诊断存在困难，因为这些疾病的临床表现通常具有明显的个体差异。在本研究中，我们注意到患有多发性肌炎的患者存在重症肌无力的临床症状，另一方面，重症肌无力患者的肌肉中存在多发性肌炎典型的组织病理学改变，这使得临床诊断常常不确定。
