金属离子传感器的研究进展：苯并咪唑磺酰胺金属配合物。
Illuminating metal-ion sensors: benzimidazolesulfonamide metal complexes.
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA.
出版信息
Inorg Chem. 2010 Nov 15;49(22):10226-8. doi: 10.1021/ic101700t. Epub 2010 Oct 13.
Abstract
The synthesis, structure, and solution spectroscopy of several (2-sulfonamidophenyl)benzimidazole metal complexes are reported. These ligands, which have been reported as selective molecular sensors for Zn(2+), readily form complexes with Co(2+), Ni(2+), Cu(2+), and Zn(2+). Surprisingly, the ligand adopts different binding modes depending on the metal ion. The work here provides insight into the coordination chemistry of these ligands, which may allow for the development of improved metal-ion sensors and metalloprotein inhibitors.
摘要
报告了几种（2-磺酰胺基苯基）苯并咪唑金属配合物的合成、结构和溶液光谱。这些配体已被报道为 Zn(2+)的选择性分子传感器，它们很容易与 Co(2+)、Ni(2+)、Cu(2+)和 Zn(2+)形成配合物。令人惊讶的是，配体的结合模式取决于金属离子。这项工作深入了解了这些配体的配位化学，这可能为开发改进的金属离子传感器和金属蛋白酶抑制剂提供了依据。
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