The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole helps genes jump.
作者信息
Rannug Agneta
机构信息
Institute of Environmental Medicine, Karolinska Institutet, S-171 77 Stockholm, Sweden.
出版信息
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18239-40. doi: 10.1073/pnas.1013653107. Epub 2010 Oct 13.
Abstract
摘要
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The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole helps genes jump.色氨酸光产物6-甲酰基吲哚并[3,2-b]咔唑有助于基因跳跃。
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2
Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2-b]carbazole (FICZ), a tryptophan photoproduct.6-甲酰基吲哚并[3,2-b]咔唑（FICZ）诱导长散在核苷酸元件-1（L1）逆转录转座
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18487-92. doi: 10.1073/pnas.1001252107. Epub 2010 Sep 17.
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The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27.芳香烃受体与 c-Maf 相互作用，促进由 IL-27 诱导的 1 型调节性 T 细胞的分化。
Nat Immunol. 2010 Sep;11(9):854-61. doi: 10.1038/ni.1912. Epub 2010 Aug 1.
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Natural mutagenesis of human genomes by endogenous retrotransposons.内源性逆转录转座子对人类基因组的自然突变。
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Mobile interspersed repeats are major structural variants in the human genome.移动散布重复序列是人类基因组中的主要结构变异。
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LINE-1 retrotransposition activity in human genomes.LINE-1 逆转座子在人类基因组中的活性。
Cell. 2010 Jun 25;141(7):1159-70. doi: 10.1016/j.cell.2010.05.021.
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High-throughput sequencing reveals extensive variation in human-specific L1 content in individual human genomes.高通量测序揭示了个体人类基因组中人类特异性 L1 含量的广泛变异。
Genome Res. 2010 Sep;20(9):1262-70. doi: 10.1101/gr.106419.110. Epub 2010 May 20.
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The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.建议的生理性芳烃受体激活剂和细胞色素P4501底物6-甲酰基吲哚并[3,2-b]咔唑存在于人体中。
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10
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