Berthod A, Jin H L, Beesley T E, Duncan J D, Armstrong D W
Department of Chemistry, University of Missouri-Rolla 65401.
J Pharm Biomed Anal. 1990;8(2):123-30. doi: 10.1016/0731-7085(90)80018-k.
Many active drugs are racemic mixtures. Because the two enantiomers of a racemate often cause different pharmacological responses, the use of optically pure isomers is desirable and may be soon required. Cyclodextrin-bonded silica gel can be used as chiral stationary phase (CSP) in liquid chromatography. The enantiomers of 25 different racemic drugs were separated on such CSPs in the reversed-phase mode. The principal features of the cyclodextrin chiral recognition mechanism are recalled and some information on future trends for cyclodextrin CSPs is provided.
许多活性药物都是外消旋混合物。由于外消旋体的两种对映体通常会引起不同的药理反应，因此使用光学纯异构体是可取的，而且可能很快就会成为必需。环糊精键合硅胶可作为液相色谱中的手性固定相（CSP）。25种不同外消旋药物的对映体在这种CSP上以反相模式进行了分离。回顾了环糊精手性识别机制的主要特点，并提供了一些有关环糊精CSP未来发展趋势的信息。
