癌症的心理反应：5-羟色胺转运体基因多态性（5-HTTLPR）的作用。

Psychological response to cancer: role of 5-HTTLPR genetic polymorphism of serotonin transporter.

机构信息

Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.

出版信息

Anticancer Res. 2010 Sep;30(9):3823-6.

PMID:20944177

Abstract

BACKGROUND

5-HTTLPR genetic polymorphism of serotonin transporter (SERT) and stressful life events facilitate depression. The aim of this investigation was therefore to determine the correlations between SERT polymorphism and mental adjustment to cancer.

PATIENTS AND METHODS

Breast cancer patients early after surgery, and subjects with various advanced tumours were recruited, evaluated using the Mini Mental Adjustment to Cancer Scale and Hospital Anxiety and Depression Scale (HADS), and genotyped.

RESULTS

In early breast cancer patients (n=53), hopelessness-helplessness (HH) and anxious preoccupation (AP) significantly correlated with depression and anxiety; avoidance (AV) correlated with anxiety. Advanced cancer patients (n=73) displayed similar correlations, and a negative correlation of HADS depression with fighting spirit (FS) and AV. The stratification for 5-HTTLPR showed that early breast cancer carriers of the L/L variant displayed a significant correlation between HH and depression.

CONCLUSION

Among early breast cancer patients, a specific set, characterized by their 5-HTTLPR variant, display differential correlations between HH and depression, with possible implications for treatment options.

摘要

背景

5-羟色胺转运体（SERT）的 5-HTTLPR 基因多态性和应激性生活事件促进了抑郁症的发生。因此，本研究旨在确定 SERT 多态性与癌症患者心理适应之间的相关性。

患者和方法

本研究招募了早期手术后的乳腺癌患者和患有各种晚期肿瘤的患者，使用简易精神调整癌症量表和医院焦虑抑郁量表（HADS）进行评估，并进行基因分型。

结果

在早期乳腺癌患者（n=53）中，绝望无助（HH）和焦虑关注（AP）与抑郁和焦虑显著相关；回避（AV）与焦虑相关。晚期癌症患者（n=73）也显示出类似的相关性，HADS 抑郁与奋斗精神（FS）和 AV 呈负相关。5-HTTLPR 的分层显示，L/L 变异型的早期乳腺癌携带者 HH 与抑郁之间存在显著相关性。