Middeldorp Christel M, de Geus Eco J C, Beem A Leo, Lakenberg Nico, Hottenga Jouke-Jan, Slagboom P Eline, Boomsma Dorret I
Department of Biological Psychology, Vrije Universiteit Amsterdam, Van der Boechorststraat 1, Amsterdam, 1081 BT, The Netherlands.
Behav Genet. 2007 Mar;37(2):294-301. doi: 10.1007/s10519-006-9139-7.
We studied the association between the short/long promotor-based length polymorphism of the serotonin transporter gene (5-HTTLPR) and neuroticism, anxiety and depression. Subjects included twins, their siblings and parents from the Netherlands Twin Register (559 parents and 1,245 offspring). Subjects had participated between one and five times in a survey study measuring neuroticism, anxiety and depression. Offspring of these families were also approached to participate in a psychiatric interview diagnosing DSM-IV major depression. Within-family and total association between 5-HTTLPR and these traits were tested. Only three of the 36 tests showed a significant effect of 5-HTTLPR (P<0.05). These effects were in opposite directions, i.e. both negative and positive regression coefficients were found for the s allele. No additive effect of the s allele was found for DSM-IV depression. Our results strongly suggest that there is no straightforward association between 5-HTTLPR and neuroticism, anxiety and depression.
我们研究了血清素转运体基因（5-HTTLPR）基于启动子的长短多态性与神经质、焦虑和抑郁之间的关联。研究对象包括来自荷兰双胞胎登记处的双胞胎、他们的兄弟姐妹及父母（559名父母和1245名后代）。这些对象曾参与一项测量神经质、焦虑和抑郁的调查研究，参与次数在一到五次之间。这些家庭的后代也被邀请参加一项诊断DSM-IV重度抑郁的精神科访谈。我们测试了5-HTTLPR与这些特质在家庭内部及总体上的关联性。在36项测试中，只有3项显示5-HTTLPR有显著效应（P<0.05）。这些效应方向相反，即对于s等位基因，我们同时发现了负向和正向回归系数。对于DSM-IV抑郁，未发现s等位基因的累加效应。我们的结果强烈表明，5-HTTLPR与神经质、焦虑和抑郁之间不存在直接关联。
