Xiong Xin, Duan Jingli, Zhai Suodi, Wang Lijue, Lan Xi
Department of Pharmacy, Peking University Third Hospital, Bejing, PR China.
Biosci Biotechnol Biochem. 2010;74(10):2151-3. doi: 10.1271/bbb.100474. Epub 2010 Oct 7.
A fast and reliable liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry (LC-APCI-MS/MS) method was developed and validated for the quantification of voriconazole in human plasma. The proposed method was validated in a linear range of 50-10,000 ng/ml, and the total run time was 1.5 min. This method was successfully used to support routine therapeutic drug monitoring of voriconazole.
建立了一种快速可靠的液相色谱-大气压化学电离串联质谱法（LC-APCI-MS/MS），并对其进行了验证，用于定量测定人血浆中的伏立康唑。该方法在50-10,000 ng/ml的线性范围内得到验证，总运行时间为1.5分钟。该方法已成功用于支持伏立康唑的常规治疗药物监测。
