Department of Clinical and Experimental Pharmacotherapy, Slovak Medical University, Bratislava, Slovakia.
Physiol Res. 2011;60(1):149-55. doi: 10.33549/physiolres.931814. Epub 2010 Oct 15.
Vitamin D status and the relationship between serum 25(OH) vitamin D concentrations and the components of insulin resistance were examined in 120 patients with chronic kidney disease stage 2 and 3. Insulin sensitivity/resistance was calculated by the quantitative insulin sensitivity check index (QUICKI). In this analysis, the prevalence of insulin resistance was 42 %. Only 17 % of patients had serum 25(OH) vitamin D concentration in the recommended range (>/=30 ng/ml), 42 % suffered from vitamin D insufficiency and 41 % had moderate vitamin D deficiency. Insulin resistance significantly correlated with serum 25(OH)D and 1,25(OH)(2)D concentrations, renal function and protein excretion rate. Our results support the increasing evidence that vitamin D deficiency may be one of the factors participating in the development of insulin resistance already in the early stages of chronic kidney disease.
在 120 例慢性肾脏病 2 期和 3 期患者中，检查了维生素 D 状态以及血清 25(OH)维生素 D 浓度与胰岛素抵抗成分之间的关系。胰岛素敏感性/抵抗性通过定量胰岛素敏感性检查指数（QUICKI）计算。在本分析中，胰岛素抵抗的患病率为 42%。只有 17%的患者血清 25(OH)维生素 D 浓度在推荐范围内（≥30ng/ml），42%的患者患有维生素 D 不足，41%的患者有中度维生素 D 缺乏。胰岛素抵抗与血清 25(OH)D 和 1,25(OH)（2）D 浓度、肾功能和蛋白排泄率显著相关。我们的结果支持越来越多的证据表明，维生素 D 缺乏可能是导致慢性肾脏病早期胰岛素抵抗发展的因素之一。
