Xu D, Yang Z
Department of Pharmacology, School of Pharmacy.
Hua Xi Yi Ke Da Xue Xue Bao. 1990 Sep;21(4):420-3.
Six dogs underwent 15 min left anterior descending (LAD) coronary artery occlusion (CAO) with 1 hour's reperfusion for 3 times. Fifteen min after CAO (control), CAO during amrinone (Amr), and CAO during isoprenaline, sigma ST (mV) and ST (mV) were 66 +/- 26 and 8 +/- 2.72 +/- 61 and 9 +/- 4.90 +/- 48 and 11 +/- 6 respectively, 24h after LAD CAO, dP/dt max (kPa/s) and HR (heart beats/min) were 483 +/- 93 and 211 +/- 36 respectively. Intravenous Amr by 1, 5, 3 and 6 mg/kg increased dP/dt max to 630 +/- 79, 583 +/- 116 and 500 +/- 148; HR to 223 +/- 44, 232 +/- 45 and 239 +/- 54; and also decreased SBP, DBP and LVEDP. Amr caused neither change in percentage of non-sinus beats, nor ventricular fibrillation. These results suggested that in myocardial infarction and arrhythmia, Amr could still be of positive inotropic effect. Amr worsened myocardial infarction in nonfailing heart, but it did not aggravated arrhythmia after myocardial infarction.
六只犬接受了三次左前降支（LAD）冠状动脉闭塞（CAO）15分钟并再灌注1小时的操作。CAO后15分钟（对照）、氨力农（Amr）期间CAO以及异丙肾上腺素期间CAO时，sigma ST（mV）和ST（mV）分别为66±26和8±2、72±61和9±4、90±48和11±6。LAD CAO后24小时，dP/dt max（kPa/s）和心率（HR，心跳/分钟）分别为483±93和211±36。静脉注射1、5、3和6mg/kg的Amr可使dP/dt max分别增至630±79、583±116和500±148；HR分别增至223±44、232±45和239±54；并且还降低了收缩压、舒张压和左心室舒张末期压力。Amr既未引起非窦性搏动百分比的变化，也未导致心室颤动。这些结果表明，在心肌梗死和心律失常中，Amr仍具有正性肌力作用。Amr会使非衰竭心脏的心肌梗死恶化，但不会加重心肌梗死后的心律失常。
