塔林 FERM 结构域并非那么 FERM。

The talin FERM domain is not so FERM.

机构信息

Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

出版信息

Structure. 2010 Oct 13;18(10):1222-3. doi: 10.1016/j.str.2010.09.002.

DOI:10.1016/j.str.2010.09.002

PMID:20947007

Abstract

The structure of the head domain of talin, an intracellular activator of integrin membrane adhesion receptors, has been solved by Elliott et al. (2010). A FERM domain can be identified in the head from sequence comparisons but, rather than having a compact structure of three subdomains, it has linear arrangement of four subdomains.

摘要

Elliott 等人（2010 年）解析了整合素膜黏附受体胞内激活物 talin 头部结构域的结构。根据序列比较，可以在头部识别出一个 FERM 结构域，但它不是由三个亚结构域组成的紧密结构，而是由四个亚结构域的线性排列组成。