Department of Gerontology, Assistance Publique-Hôpitaux de Paris (Hôpital Broca), France.
J Aging Health. 2011 Mar;23(2):329-46. doi: 10.1177/0898264310381277. Epub 2010 Oct 14.
To carry out meta-analyses on psychotropic drugs and to provide an update of the risk of falling in the elderly people related to psychotropic drugs.
Meta-analyses of studies on psychotropic drugs.
177 studies are included, of which 71 have data on risk factors associated with psychotropic drugs. The odds ratio and 95% Cl for associations between use of psychotropic drugs and fall are 1.78 and 1.57-2.01, respectively. This result is statistically heterogeneous. This heterogeneity disappears in the group of very old participants for each class.
Our study confirms the association between falls in the elderly people and psychotropic drugs. These results are similar to those of former meta-analyses but with different methods. It shows that these meta-analyses on psychotropic drugs have a small impact on prescribing habits. They only give evidence to support the association between psychotropic drugs and falls even if there is no proven link.
对精神药物进行荟萃分析，更新与精神药物相关的老年人跌倒风险。
精神药物研究的荟萃分析。
纳入 177 项研究，其中 71 项研究有精神药物相关风险因素的数据。精神药物使用与跌倒之间的比值比和 95%置信区间分别为 1.78 和 1.57-2.01。该结果存在统计学异质性。在每个类别中非常高龄参与者组中，这种异质性消失。
本研究证实了老年人跌倒与精神药物之间的关联。这些结果与之前的荟萃分析相似，但方法不同。这表明，这些精神药物的荟萃分析对处方习惯的影响很小。它们仅提供了支持精神药物与跌倒之间关联的证据，即使没有证明存在联系。
