Inagaki Hitoshi, Yokoyama Tadashi, Kikuchi Manabu, Yokoyama Yasuhisa
Department of Surgery, Yokoyama Hospital for Gastroenterological Diseases.
Gan To Kagaku Ryoho. 2010 Oct;37(10):1953-6.
A 71-year-old man, whose chief complaint was a faecal occult blood, had gastrointestinal endoscopy and gastric cancer was diagnosed. CT scan and intraoperative findings revealed metastatic liver tumors. We performed total gastrectomy with D2 lymph dissection, partial hepatic resections and microwave coagulation therapy. Small cell carcinoma of the stomach was diagnosed by histopathological findings. We used combination chemotherapy consisting of carboplatin, epirubicin, etoposide and 5-FU was performed. After one course, he suffered from leucopenia and agranulocytosis of grade 3, thrombocytopenia of grade 4, so we reduced the dose and performed 6 courses in total. The patient remains alive without recurrence 48 months after operation. We conclude that adjuvant chemotherapy was effective for small cell carcinoma of the stomach, which was to be considered to have a poor prognosis.
一名71岁男性，主要症状为粪便潜血，接受了胃肠内镜检查，被诊断为胃癌。CT扫描和术中发现显示有肝转移瘤。我们进行了D2淋巴结清扫的全胃切除术、部分肝切除术和微波凝固治疗。组织病理学检查结果诊断为胃小细胞癌。我们采用了由卡铂、表柔比星、依托泊苷和5-氟尿嘧啶组成的联合化疗。一个疗程后，他出现了3级白细胞减少和粒细胞缺乏症、4级血小板减少症，因此我们降低了剂量，总共进行了6个疗程。患者术后48个月仍存活且无复发。我们得出结论，辅助化疗对胃小细胞癌有效，胃小细胞癌通常被认为预后较差。
