Medizinische Klinik und Poliklinik D, University of Münster, Münster, Germany.
Kidney Int. 2010 Nov;78(9):836-7. doi: 10.1038/ki.2010.282.
Factor inhibiting HIF-1 (FIH1) inhibits the activity of hypoxia-inducible factor 1 (HIF-1) by preventing HIF-1α from binding to p300/CBP. Schödel et al. demonstrate that, in the kidney, FIH1 is expressed selectively in the distal tubules and podocytes. Although FIH1 functions as a transcriptional repressor of HIF target genes in tubular cells, it does not do so in podocytes. This study suggests that FIH1 may have diverse implications for distal tubular function and podocyte biology.
因子抑制低氧诱导因子 1（FIH1）通过阻止低氧诱导因子 1α（HIF-1α）与 p300/CBP 结合来抑制低氧诱导因子 1（HIF-1）的活性。Schödel 等人证明，在肾脏中，FIH1 选择性地在远端肾小管和足细胞中表达。尽管 FIH1 在管状细胞中作为 HIF 靶基因的转录抑制剂发挥作用，但在足细胞中却没有。本研究表明，FIH1 可能对远端肾小管功能和足细胞生物学具有多种影响。
