卵巢功能衰竭后保留残余卵巢组织对老年小鼠骨质流失的影响有限。
Retaining Residual Ovarian Tissue following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice.
作者信息
Craig Zelieann R, Marion Samuel L, Funk Janet L, Bouxsein Mary L, Hoyer Patricia B
机构信息
Department of Veterinary Biosciences, University of Illinois, 2001 S. Lincoln Avenue, Urbana, IL 61802, USA.
出版信息
J Osteoporos. 2010 Jun 29;2010:157323. doi: 10.4061/2010/157323.
Previous work showed that retaining residual ovarian tissue protects young mice from accelerated bone loss following ovarian failure. The present study was designed to determine whether this protection is also present in aged animals. Aged (9-12 months) C57BL/6Hsd female mice were divided into: CON (vehicle), VCD (160 mg/kg; 15d), or OVX (ovariectomized). Lumbar BMD was monitored by DXA and μCT used to assess vertebral microarchitecture. BMD was not different between VCD and CON at any time point but was lower (P < .05) than baseline, starting 1 month after ovarian failure in VCD and OVX mice. Following μCT analysis there were no differences between CON and VCD, but OVX mice had lower bone volume fraction, trabecular thickness, and a trend for decreased connectivity density. These findings provide evidence that retention of residual ovarian tissue may protect aged follicle-depleted mice from accelerated bone loss to a lesser extent than that observed in young mice.
先前的研究表明，保留残余卵巢组织可保护年轻小鼠免于卵巢功能衰竭后加速的骨质流失。本研究旨在确定这种保护作用在老龄动物中是否也存在。将老龄（9 - 12个月）C57BL/6Hsd雌性小鼠分为：对照组（赋形剂）、VCD组（160mg/kg；15天）或去卵巢组（卵巢切除）。通过双能X线吸收法监测腰椎骨密度，并使用显微CT评估椎体微结构。在任何时间点，VCD组和对照组之间的骨密度均无差异，但在VCD组和去卵巢组小鼠中，自卵巢功能衰竭1个月后，骨密度低于基线水平（P < 0.05）。经过显微CT分析，对照组和VCD组之间没有差异，但去卵巢组小鼠的骨体积分数、小梁厚度较低，并且连接密度有降低的趋势。这些发现提供了证据，表明保留残余卵巢组织可能在一定程度上保护老龄卵泡耗竭小鼠免于加速的骨质流失，但其保护程度低于在年轻小鼠中观察到的情况。
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