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人类减数分裂前期卵母细胞中交叉互换的直接测量

A direct measurement of crossing over in human prophase oocytes.

作者信息

Hawley R Scott

机构信息

Stowers Institute for Medical Research, Kansas City, MO 64110, USA.

出版信息

F1000 Biol Rep. 2009 Nov 16;1:86. doi: 10.3410/B1-86.

Abstract

The nature of the relationship between crossing over and failed segregation in human oocytes is of obvious interest. A recent paper by Cheng and colleagues provides important insights into the distribution of crossover events (as marked by MLH1 foci) in human oocytes and raises complex questions regarding discrepancies between direct cytological assessment of exchange and measurement of crossing over by linkage analysis.

摘要

人类卵母细胞中交叉互换与分离失败之间关系的本质显然备受关注。Cheng及其同事最近发表的一篇论文对人类卵母细胞中交叉互换事件(以MLH1焦点标记)的分布提供了重要见解,并就交换的直接细胞学评估与连锁分析测量交叉互换之间的差异提出了复杂问题。

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本文引用的文献

1
Meiotic recombination in human oocytes.人类卵母细胞中的减数分裂重组。
PLoS Genet. 2009 Sep;5(9):e1000661. doi: 10.1371/journal.pgen.1000661. Epub 2009 Sep 18.
2
Broad-scale recombination patterns underlying proper disjunction in humans.人类正确分离背后的大规模重组模式。
PLoS Genet. 2009 Sep;5(9):e1000658. doi: 10.1371/journal.pgen.1000658. Epub 2009 Sep 18.
8
Non-disjunction of chromosome 13.13号染色体不分离
Hum Mol Genet. 2007 Aug 15;16(16):2004-10. doi: 10.1093/hmg/ddm148. Epub 2007 Jun 21.

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