Hawley R Scott
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
F1000 Biol Rep. 2009 Nov 16;1:86. doi: 10.3410/B1-86.
The nature of the relationship between crossing over and failed segregation in human oocytes is of obvious interest. A recent paper by Cheng and colleagues provides important insights into the distribution of crossover events (as marked by MLH1 foci) in human oocytes and raises complex questions regarding discrepancies between direct cytological assessment of exchange and measurement of crossing over by linkage analysis.
人类卵母细胞中交叉互换与分离失败之间关系的本质显然备受关注。Cheng及其同事最近发表的一篇论文对人类卵母细胞中交叉互换事件(以MLH1焦点标记)的分布提供了重要见解,并就交换的直接细胞学评估与连锁分析测量交叉互换之间的差异提出了复杂问题。