子宫肌瘤管理的进展
Advances in the management of uterine fibroids.
作者信息
Munro Kirsty I, Critchley Hilary Od
机构信息
Centre for Reproductive Biology, University of Edinburgh, The Queen&s Medical Research Institute Little France Crescent, Edinburgh EH16 4TJ UK.
出版信息
F1000 Med Rep. 2009 Sep 28;1:74. doi: 10.3410/M1-74.
Abstract
Uterine fibroids are extremely common, with major surgery the current main management option; uterine artery embolisation is an alternative, but risks to fertility are unclear. Minimally invasive procedures are becoming more commonly performed via both the hysteroscope and laparoscope, minimising recovery time for patients. Recently, small doses of progesterone receptor modulators (mifepristone and asoprisnil) have been shown to be effective in reducing menstrual blood loss and fibroid size. Progress from here should include the development of a well-tolerated oral preparation that will maintain fertility.
摘要
子宫肌瘤极为常见，目前主要的治疗选择是大型手术；子宫动脉栓塞术是一种替代方法，但对生育的风险尚不清楚。微创手术正通过宫腔镜和腹腔镜越来越普遍地开展，将患者的恢复时间减至最短。最近，已证明小剂量的孕激素受体调节剂（米非司酮和阿索普尼尔）在减少月经量和肌瘤大小方面有效。此后的进展应包括研发一种耐受性良好且能维持生育能力的口服制剂。
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