冷应激对多囊卵巢综合征大鼠的影响：建模前后。
The effect of cold stress on polycystic ovary syndrome in rat: before and during modeling.
机构信息
Vali-e-Asr Reproductive Health Research Center, Imam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Arch Gynecol Obstet. 2011 Sep;284(3):651-7. doi: 10.1007/s00404-010-1711-y. Epub 2010 Oct 15.
PURPOSE
The aim of this study was the evaluation effects of a chronic intermittent cold stress regimen before and during PCO modeling in rat.
METHODS
Forty-eight rats were treated with estradiol valerate for 60 days in order to induction of follicular cysts (PCO modeling). Rats were divided into two groups: (1) before (cold stress 3 weeks then PCO modeling) and (2) during modeling (cold stress and PCO simultaneous).
RESULTS
The biochemical and histological findings show that in simultaneous cold stress and estradiol injection group PCOS modeling has been done successfully and in the other group cold stress prevents induction of PCO in rats.
CONCLUSION
The present study is the first survey that reports 3-week chronic stress before estradiol injection prevents the induction of PCO in rats.
目的
本研究旨在评估在大鼠 PCO 模型建立前后进行慢性间歇性冷应激处理的效果。
方法
48 只大鼠接受戊酸雌二醇治疗 60 天，以诱导卵泡囊肿（PCO 模型建立）。大鼠分为两组：（1）模型建立前（冷应激 3 周后进行 PCO 模型建立）和（2）模型建立期间（冷应激和 PCO 同时进行）。
结果
生化和组织学结果表明，在同时进行冷应激和雌二醇注射的 PCOS 模型建立组中，PCO 模型成功建立，而在另一组中，冷应激可防止大鼠 PCO 的诱导。
结论
本研究首次报道了在雌二醇注射前进行 3 周慢性应激可预防大鼠 PCO 的诱导。
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