Ciprandi Giorgio, Tosca Maria Angela, Capasso Michele
Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino-University of Genoa, Genoa, Italy.
J Asthma. 2010 Dec;47(10):1142-7. doi: 10.3109/02770903.2010.527026. Epub 2010 Nov 1.
Nowadays, the measure of the fractional concentration of exhaled nitric oxide (FeNO) enables to assess airway inflammation during an office visit and there is international consensus on this testing methodology. The aim of this study was to evaluate whether FeNO measurement is predictable for bronchial hyperreactivity (BHR) in children with allergic rhinitis, asthma, or both.
Two hundred and eighty children with allergic rhinitis, allergic asthma, or both were evaluated. Bronchial function (FEV₁ and FEF(25-75)), BHR (assessed by methacholine challenge), FeNO, and sensitizations were assessed.
Bronchial function, BHR, and FeNO were significantly different in the three groups (p < .001). A strong inverse correlation between FeNO and BHR was found in patients with asthma and with asthma and rhinitis (r = -0.63 and r = -0.61, respectively). A cutoff of 32 ppb of FeNO was a predictive factor for BHR.
This study highlights the relevance of FeNO as possible marker for BHR in allergic children and underlines the close link between upper and lower airways.
如今，呼出一氧化氮分数浓度（FeNO）的测量能够在门诊就诊时评估气道炎症，并且在这种检测方法上存在国际共识。本研究的目的是评估FeNO测量对于患有过敏性鼻炎、哮喘或两者皆有的儿童的支气管高反应性（BHR）是否具有预测性。
对280名患有过敏性鼻炎、过敏性哮喘或两者皆有的儿童进行了评估。评估了支气管功能（FEV₁和FEF(25 - 75)）、BHR（通过乙酰甲胆碱激发试验评估）、FeNO和致敏情况。
三组之间的支气管功能、BHR和FeNO存在显著差异（p <.001）。在哮喘患者以及哮喘合并鼻炎患者中，发现FeNO与BHR之间存在强烈的负相关（分别为r = -0.63和r = -0.61）。FeNO为32 ppb是BHR的一个预测因素。
本研究强调了FeNO作为过敏性儿童BHR可能标志物的相关性，并强调了上、下气道之间的密切联系。
