Waddingham S, Riffee W R, Belknap J K, Sheppard J R
Res Commun Chem Pathol Pharmacol. 1978 May;20(2):207-20.
C57BL/6J and DBA/2J inbred mice were assayed for beta-adrenergic receptor density following seven days of chronic phenobarbital intoxication. These physically dependent mice showed a greater brain receptor density than did the control, while acute intoxication to phenobarbital produced no significant effects. C57BL/6J mice showed a higher average receptor density than did the DBA/2J mice under all conditions. These findings support the hypothesis that chronic barbiturate intoxication leads to a receptor supersensitivity which may play a role in the phenomena of functional tolerance and physical dependence.
对C57BL/6J和DBA/2J近交系小鼠进行了为期七天的慢性苯巴比妥中毒后β-肾上腺素能受体密度检测。这些身体依赖型小鼠的脑受体密度高于对照组，而苯巴比妥急性中毒则无显著影响。在所有条件下，C57BL/6J小鼠的平均受体密度均高于DBA/2J小鼠。这些发现支持了以下假设：慢性巴比妥类药物中毒会导致受体超敏反应，这可能在功能性耐受和身体依赖现象中起作用。
