Benasso M, Blengio F, Merlano M, Cavallari M, Bacigalupo A, Scala M, Mereu P, Scasso F, Garaventa G
Divisione di Oncologia Medica dell'Istituto Tumori di Genova.
Acta Otorhinolaryngol Ital. 1990 Sep-Oct;10(5):439-45.
Malignant lymphomas account for 3% of all malignant disease in the head and neck area. Twenty-five to fifty percent of all lymphomas arising in this region develop in extra-nodal structures, mostly in the Waldeyer ring. Lymphomas of the Waldeyer ring are comparable to any other lymphomas and prognosis is strictly related to stage and histology. The present paper reports 51 patients with malignant lymphomas arising in the head and neck (25 patients with Waldeyer ring involvement) recorded at the National Institute for Cancer Research, Genoa, Italy, from 1985 to the present. The characteristics of patients with Waldeyer ring involvement are comparable to those reported in the literature. Differences can be found in the median age (older in the present series) and in the incidence of Hodgkin's disease (8%). Patients were treated according to stage: stage I and II received radiation therapy and, in a few selected patients, this was combined with chemotherapy; stage III-IV received chemotherapy followed, in a few selected patients, by radiation therapy. In the present series, survival was related to the involvement of the Waldeyer ring: analysis has shown that survival is better in those patients with only nodal involvement. Nevertheless, these patients usually have a more advanced stage (p = less than 0.03). This finding is quite surprising since all the known prognostic factors are better in the Waldeyer group.
恶性淋巴瘤占头颈部所有恶性疾病的3%。该区域发生的所有淋巴瘤中，25%至50%发生于结外结构，主要位于瓦尔代尔环。瓦尔代尔环淋巴瘤与其他任何淋巴瘤类似，预后与分期和组织学密切相关。本文报告了1985年至今在意大利热那亚国家癌症研究所记录的51例头颈部恶性淋巴瘤患者（25例累及瓦尔代尔环）。累及瓦尔代尔环患者的特征与文献报道的相似。在中位年龄（本系列中年龄较大）和霍奇金病发病率（8%）方面存在差异。患者根据分期进行治疗：I期和II期接受放射治疗，少数特定患者联合化疗；III - IV期接受化疗，少数特定患者随后接受放射治疗。在本系列中，生存与瓦尔代尔环受累情况有关：分析表明，仅累及淋巴结的患者生存情况更好。然而，这些患者通常分期更晚（p < 0.03）。这一发现相当令人惊讶，因为所有已知的预后因素在瓦尔代尔组中都更好。
