Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.
J Ethnopharmacol. 2011 Jan 27;133(2):412-9. doi: 10.1016/j.jep.2010.10.012. Epub 2010 Oct 13.
Nowadays diabetic nephropathy (DN) has become a serious problem. Astragalus membranaceus is a traditional herb used for thousands of years in China and East Asia for kidney disease. In modern medicine, Astragalus shows significant renal protective effect in DN. We aimed to systematically review the randomized and semi-randomized control trials to ascertain its role in the treatment of DN.
PUBMED, MEDLINE, Chinese journal full-test database (CJFD), Chinese biological and medical database were searched by computer and manual searching. Two assessors independently reviewed each trial. 25 studies comprising 21 RCTs and 4 CCTs were involved including 1804 patients (945 in treatment group and 859 in control group).
Astragalus injection had more therapeutic effect in DN patients including renal protective effect (BUN, SCr, CCr and urine protein) and systemic state improvement (serum albumin level) compared with the control group.
This study investigates the effect of Astragalus in DN patients. It suggests that although of unknown bioactive ingredients and mechanism of renal protection, the role of Astragalus in the treatment of DN can be disclosed and of profound significance.
如今，糖尿病肾病（DN）已成为一个严重的问题。黄芪是一种传统草药，在中国和东亚地区被使用了数千年，用于治疗肾脏疾病。在现代医学中，黄芪在糖尿病肾病中显示出显著的肾脏保护作用。我们旨在系统地综述随机和半随机对照试验，以确定其在治疗 DN 中的作用。
计算机检索 PUBMED、MEDLINE、中国期刊全文数据库（CJFD）、中国生物医学文献数据库，并辅以手工检索。两名评估员独立地对每一项试验进行了评价。共纳入 25 项研究，包括 21 项 RCT 和 4 项 CCT，共纳入 1804 例患者（治疗组 945 例，对照组 859 例）。
与对照组相比，黄芪注射液在糖尿病肾病患者中具有更好的治疗效果，包括肾脏保护作用（BUN、SCr、CCr 和尿蛋白）和全身状态改善（血清白蛋白水平）。
本研究调查了黄芪在糖尿病肾病患者中的作用。虽然其生物活性成分和肾脏保护机制尚不清楚，但黄芪在糖尿病肾病治疗中的作用可以被揭示，这具有深远的意义。
