Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Japan.
Radiother Oncol. 2011 Jan;98(1):68-73. doi: 10.1016/j.radonc.2010.09.017. Epub 2010 Oct 14.
To evaluate the potential of apparent diffusion coefficient (ADC) value before carbon ion radiotherapy (C-ion RT) for malignant mucosal melanoma (MMM) to predict prognosis.
We recruited 37 patients with MMM in the head and neck treated by C-ion RT with concomitant chemotherapy. Univariate and multivariate analyses of minimum ADC, mean ADC, tumor volume, age, PS, and gender were performed to identify prognostic factors.
The 3-year local control rate, distant metastasis-free survival rate and overall survival rate of all patients were 81.1%, 37.6% and 65.3%, respectively, with a median follow-up period of 19.0 months. In univariate analyses, lower minimum ADC (≤0.6380 × 10(-3) mm(2)/s) and lower mean ADC (≤1.1523 × 10(-3) mm(2)/s) were unfavorable prognostic factors for distant metastasis (p=0.029 and p=0.014, respectively), and lower minimum ADC was an unfavorable prognostic factor for overall survival (p=0.019). However, there was no significant prognostic factor of local control including ADC value. In multivariate analyses, only minimum ADC was selected as a prognostic factor of distant metastasis-free survival and overall survival (p=0.015 and p=0.006, respectively).
Minimum ADC can be a prognostic factor of MMM in the head and neck after C-ion RT.
评估碳离子放射治疗（C-ion RT）前表观扩散系数（ADC）值对恶性黏膜黑色素瘤（MMM）的预测预后的潜在价值。
我们招募了 37 例头颈部接受 C-ion RT 联合化疗治疗的 MMM 患者。对最小 ADC 值、平均 ADC 值、肿瘤体积、年龄、PS 和性别进行单因素和多因素分析，以确定预后因素。
所有患者的 3 年局部控制率、远处无转移生存率和总生存率分别为 81.1%、37.6%和 65.3%，中位随访时间为 19.0 个月。单因素分析显示，最小 ADC 值（≤0.6380×10(-3)mm(2)/s）和平均 ADC 值（≤1.1523×10(-3)mm(2)/s）较低是远处转移的不良预后因素（p=0.029 和 p=0.014），而最小 ADC 值较低是总生存的不良预后因素（p=0.019）。然而，包括 ADC 值在内的局部控制没有显著的预后因素。多因素分析显示，只有最小 ADC 值被选为远处无转移生存率和总生存率的预后因素（p=0.015 和 p=0.006）。
最小 ADC 值可作为 C-ion RT 后头颈部 MMM 的预后因素。
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