Division of Fixed Prosthodontics, Department of Oral & Maxillofacial Rehabilitation, Kanagawa Dental College, 82 Inaoka Yokosuka, Kanagawa 238-8580, Japan.
J Prosthodont Res. 2011 Apr;55(2):89-97. doi: 10.1016/j.jpor.2010.09.006. Epub 2010 Oct 15.
We used functional magnetic resonance imaging (fMRI) to investigate the change in brain regional activity during gum chewing when edentulous subjects switched from mandibular complete dentures to implant-supported removable overdentures.
Four edentulous patients (3 males and 1 female, aged 64 to 79 years) participated in the study. All subjects received a set of new maxillary and mandibular complete dentures (CD), followed by a maxillary complete denture and a new mandibular implant-supported removable overdentures (IOD). A 3-T fMRI scanner produced images of the regional brain activity for each subject that showed changes in the blood-oxygenation-level-dependent (BOLD) contrast in the axial orientation during gum-chewing with CD and IOD.
Region-of-interest analysis showed that IOD treatment significantly suppressed chewing-induced brain activity in the prefrontal cortex. The chewing-induced brain activities in the primary sensorimotor cortex and cerebellum tended to decrease with IOD treatment, however they did not reach to significance level. There was no change in brain activity in the supplementary motor area, thalamus and insula between gum chewing with CD and IOD. Group comparison using statistical parametrical mapping further showed that, within the prefrontal cortex, the neural activity of the frontal pole significantly decreased during gum-chewing with IOD when compared to that with CD (P<0.05).
Despite the limitation of a small sample size, these results suggest that the gum-chewing task in elderly edentulous patients resulted in differential neural activity in the frontal pole within the prefrontal cortex between the 2 prosthodontic therapies-mandibular CD and IOD.
我们使用功能磁共振成像（fMRI）来研究无牙颌患者从下颌全口义齿转换为种植体支持的可摘局部义齿时咀嚼口香糖时大脑区域活动的变化。
4 名无牙颌患者（3 名男性和 1 名女性，年龄 64 至 79 岁）参加了这项研究。所有患者均接受了一套新的上颌和下颌全口义齿（CD），然后是上颌全口义齿和新的下颌种植体支持的可摘局部义齿（IOD）。3-T fMRI 扫描仪为每位受试者产生了轴向方向在咀嚼口香糖时与 CD 和 IOD 相关的血氧水平依赖性（BOLD）对比的大脑区域活动图像。
感兴趣区域分析表明，IOD 治疗显著抑制了咀嚼诱导的前额叶皮层的大脑活动。随着 IOD 治疗，初级感觉运动皮层和小脑的咀嚼诱导脑活动趋于减少，但未达到显著水平。在补充运动区、丘脑和脑岛中，咀嚼口香糖时 CD 和 IOD 之间的大脑活动没有变化。使用统计参数映射的组间比较进一步表明，在前额叶皮层中，与咀嚼口香糖时的 CD 相比，IOD 时咀嚼口香糖时额极的神经活动显著降低（P<0.05）。
尽管样本量较小存在局限性，但这些结果表明，在这两种义齿治疗方法（下颌 CD 和 IOD）中，咀嚼口香糖任务在老年无牙颌患者的前额叶皮层内导致了额极的神经活动存在差异。
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