Research Center, Green Cross Corporation, Giheung-Gu, Yongin, Gyeonggi-Do, Republic of Korea.
Bioorg Med Chem Lett. 2010 Dec 1;20(23):7046-9. doi: 10.1016/j.bmcl.2010.09.103. Epub 2010 Sep 29.
Novel C-aryl glucoside SGLT2 inhibitors containing pyrimidine motif were designed and synthesized for biological evaluation. Among the compounds assayed, pyrimidine containing methylthio moiety 11 g demonstrated the best in vitro inhibitory activity against SGLT2 in this series to date (IC(50)=10.7 nM).
设计并合成了含有嘧啶基序的新型 C-芳基葡萄糖苷 SGLT2 抑制剂，用于生物学评价。在所测试的化合物中，含有嘧啶甲硫基部分的化合物 11g 表现出迄今为止该系列对 SGLT2 的最佳体外抑制活性（IC50=10.7 nM）。
